| Pair Name | Norizalpinin, Imatinib | ||
| Phytochemical Name | Norizalpinin (PubChem CID: 5281616 ) | ||
| Anticancer drug Name | Imatinib (PubChem CID: 123596 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Norizalpinin, Imatinib | |||
| Disease Info | [ICD-11: 2B33.4] | Leukemia | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
| Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
| Down-regulation | Expression | CDK1 | hsa983 | |
| Down-regulation | Expression | CDK4 | hsa1019 | |
| Down-regulation | Expression | RB1 | hsa5925 | |
| In Vitro Model | K-562 | Blast phase chronic myelogenous leukemia | Homo sapiens (Human) | CVCL_0004 |
| KCL-22 | Chronic myelogenous leukemia, BCR-ABL1 positive | Homo sapiens (Human) | CVCL_2091 | |
| Result | Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells | |||
| No. | Title | Href |
|---|---|---|
| 1 | Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells. Cancer Lett. 2008 Jul 8;265(2):289-97. doi: 10.1016/j.canlet.2008.02.025. | Click |
